The Carcino Foundation

What is Anal Cancer?

Anal cancer is a malignancy originating in the anus—the distal opening of the gastrointestinal tract. Most commonly, it is a squamous cell carcinoma arising in the anal canal. Less frequent types include adenocarcinoma, small-cell carcinoma, and melanoma.

Types of Anal Cancer

Anal cancer is categorized based on the type of cells from which it originates. Understanding the types is crucial because treatment and prognosis vary differently.

Squamous Cell Carcinoma (SCC) Most common type (about 85–90% of all cases).

It arises from squamous epithelial cells lining the anal canal.

Often linked to Human Papillomavirus (HPV) infection, especially HPV-16.

Subtypes include: 1)Keratinizing: resembles skin-like cells; more common in external anal margin. 2)Non-keratinizing: located deeper in the anal canal.

Adenocarcinoma Develops from glandular cells, usually near the anal glands or rectum.

Rare (less than 10% of cases).

Resembles colorectal cancer in behavior and treatment.

Basaloid or Cloacogenic Carcinoma Arises near the transformation zone, where glandular and squamous cells meet.

Considered a variant of squamous carcinoma.

More aggressive but often treated like SCC.

Melanoma of the Anus Rare and highly aggressive.

Originates from melanocytes, the pigment-producing cells.

May present as a dark lump or ulcer in or around the anus.

Small Cell Carcinoma / Neuroendocrine Tumors Extremely rare and highly malignant.

Requires systemic treatment (similar to small cell lung cancer).

LocationOccurs in the anal canal (approx. 4 cm in length), the internal passage from the rectum to the anus StagesStaging follows the TNM system, from Stage I (localized to the anal canal) to Stage IV (metastasis to distant organs) . German data indicate 5-year survival: Stage I: 77–90 %

Stage II: 67–75 %

Stage IIIA/B: 51–64 %

Stage IV: 5–15 %

Symptoms

Common signs include: Anal or rectal bleeding or blood in stool

Pain, pressure, or a lump

Persistent itching or discharge

Altered bowel habits, such as frequency or stool caliber changes

In later stages: fatigue, weight loss, incontinence

Statistics and Extent:

It accounts for approximately 0.5 % of all new cancers.

Incidence has risen since the 1990s, particularly among women over 65, now reaching 11.4 per 100,000 in white women. my.clevelandclinic.org+15thesun.co.uk+15en.wikipedia.org+15.

The 5-year survival in the U.S. is approximately 68 %, with based-on stage range from 77–90 % in early-stage to 36 % in metastatic diseases.

Prevention of Anal Cancer

Preventive strategies are especially important due to the strong link between anal cancer and modifiable risk factors, especially HPV.

HPV Vaccination The most effective preventive tool. Protects against HPV types 16 and 18, which cause ~90% of anal cancers.

Recommended for:

All adolescents before sexual activity begins. Catch-up vaccination up to age 26 (and sometimes to age 45 after shared decision-making).

Safe Sexual Practices Using condoms during anal intercourse lowers risk but doesn’t eliminate it. Limiting the number of sexual partners reduces HPV transmission risk.
Smoking Cessation Smoking damages epithelial cells and weakens immune defenses, allowing persistent HPV infection.

Smokers are 2–3X more likely to develop anal cancer.

Regular Screening for High-Risk Groups Especially men who have sex with men (MSM), people with HIV, and organ transplant recipients.

Screening with anal Pap tests or high-resolution anoscopy can catch precancerous lesions.

Diagnosis of Anal Cancer

Early and accurate diagnosis is essential for effective treatment. The process typically includes:

History and Physical Exam A doctor asks about symptoms (bleeding, pain, itching, lumps) and other illness history to diagnose the case better. Digital Rectal Examination (DRE): A gloved finger is inserted into the rectum to feel for masses or irregularities.
Anoscopy A short, rigid tube (anoscope) with a light is inserted into the anal canal. Provides a clear view of the lining. Often done in outpatient settings.
Proctoscopy / Sigmoidoscopy For viewing deeper into the rectum and lower colon, especially if the tumor is high up. A flexible scope may be used.
Biopsy Gold standard for diagnosis.

A small tissue sample is removed during anoscopy or proctoscopy and examined under a microscope. Determines: Cancer type (e.g., squamous cell or adenocarcinoma) Grade (how abnormal the cells look)

Imaging for Staging Used to determine if the cancer has spread: MRI pelvis: Best for assessing local spread to muscles or sphincters.

CT scan (abdomen and pelvis): Checks lymph nodes and distant organs.

PET scan: Detects metabolically active cancer cells anywhere in the body.

Endoanal Ultrasound: Uses sound waves to assess tumor depth and local lymph nodes.

Anal Pap Smear (for screening, not diagnosis) Similar to cervical Pap test.

Gathers cells from the anal canal to check for anal intraepithelial neoplasia (AIN)—a precancerous condition.

Mostly used in high-risk populations (MSM, HIV+ individuals).

Treatment Options for Anal Cancer

Treatment depends on the cancer type, stage, location, and overall health of the patient. For most people, combined chemoradiation is the standard. Here's a breakdown:

Chemoradiation Therapy (CRT) This is the first-line treatment for most patients with squamous cell carcinoma, even in locally advanced stages. Chemotherapy Drugs Used:

5-fluorouracil (5-FU): slows cancer cell growth.

Mitomycin C: enhances the effect of radiation.

Sometimes, cisplatin is used as an alternative.

Radiation Therapy:

High-energy X-rays target cancer cells in the anus and regional lymph nodes.

Administered in daily sessions over 5–6 weeks.

Benefits:

Avoids surgery.

Preserves the anal sphincter (allows bowel control).

High cure rates (70–90% in early-stage).

Surgery Surgery is reserved for: Small, superficial tumors (especially those on the anal margin).

Cases where chemoradiation fails (salvage surgery).

Rare tumor types like melanoma or adenocarcinoma.

Types of surgery: Local Excision: For small tumors; involves removing the tumor with a margin of healthy tissue.

Abdominoperineal Resection (APR):

Removal of anus, rectum, and part of the sigmoid colon.

Requires a permanent colostomy (opening in the abdomen for waste removal).

Used when CRT fails or a tumor invades the sphincter complex.

Targeted Therapy & Immunotherapy (for advanced or metastatic disease) Immunotherapy (Checkpoint Inhibitors):

Drugs like nivolumab and pembrolizumab (anti-PD-1) are used for cancers that do not respond to other treatments.

Work by helping the immune system attack cancer cells.

Targeted Therapy (experimental/under trial):

Focuses on molecular abnormalities in tumors (like EGFR).

Side Effects of Treatment and Their Management

From Chemoradiation: Skin reactions:

Redness, blistering, and peeling in the anal and groin area.

Management: Gentle skin care, sitz baths, and corticosteroid creams.

Gastrointestinal Symptoms:

Diarrhea, urgency, cramping.

Management: Anti-diarrheal meds (like loperamide), dietary changes.

Urinary issues:

Frequency, burning sensation.

Management: Hydration, urinary alkalinizers if needed.

Fatigue:

Common and can persist for weeks.

Management: Light physical activity, nutrition, rest.

Sexual dysfunction:

Vaginal dryness, discomfort, or erectile dysfunction.

Management: Lubricants, counseling, pelvic therapy.

Hematologic toxicity:

Drop in white blood cells, platelets.

Monitoring: Frequent blood counts; treatment delays if needed.

Anal strictures or fibrosis (long-term):

Narrowing of anal canal.

May require dilation or surgical correction.

Anal cancer is a rare but increasingly common cancer, especially among older women. It is closely linked to HPV, smoking, and immunosuppression. The best approach is early detection through clinical awareness and targeted screening, with HPV vaccination and lifestyle changes to reduce risk. Standard treatment—chemoradiation—offers high cure rates, with supportive care aiding recovery and quality of life.

FAQs – Frequently Asked Questions

Q1. Is anal cancer contagious? No. Cancer itself is not contagious, though the main cause—HPV—is sexually transmitted. Q2. Can anal cancer be completely cured? Yes, particularly when detected early. Over 80% of stage I and II cases respond well to treatment with no recurrence. Q3. Can I work or go to school during treatment? It depends on your individual tolerance to chemoradiation. Many experience fatigue and need time off, especially in the later weeks of treatment. Q4. Do I need a colostomy bag? Not usually. Chemoradiation preserves the anus in most cases. A permanent colostomy is only needed if surgery is required due to treatment failure or recurrence. Q5. How often should I get follow-up care? Every 3–6 months for the first 2 years

Then every 6–12 months up to year 5

Surveillance includes physical exams, anoscopy, and imaging if needed.

Q6. Will HPV vaccination help me if I already have anal cancer? No. Vaccination does not treat existing cancer, but it helps prevent future HPV-related cancers, including recurrence. Q7. Can I have children after treatment? Radiation can affect fertility, especially in women.

Discuss fertility preservation options (like egg or sperm banking) before starting treatment.

Q8. Are there support groups or counseling options? Yes. Most cancer centers have oncology social workers, mental health professionals, and support groups (in-person or online) to help with the emotional impact of the diagnosis.